This is one of the 3 brands of trans-Resveratrol that I give 5 stars. The other 2 are Country Life and Healthy Origins. They have improved my colitis significantly after a few months of usage. (Colitis is an inflammation and pain of the colon and sometimes also rectal inflammation called proctitis or prolapsed hemorrhoids. They probably are all the same ailment - inflammation of the intestinal tract - with different medical names.) Healthy Origins has more trans-Resveratrol (300mg) in 1 cap and is slightly cheaper. However this brand with 250mg of trans-Resveratrol in 1 cap has more synergistic ingredients added.